Welcome Guest! Login Create Account

Swine (Sus scrofa) as a Model of Postinfarction Mitral Regurgitation and Techniques to Accommodate Its Effects during Surgical Repair.

See comment in PubMed Commons below
Comp Med. 2016;66(4):290-9.

Swine (Sus scrofa) as a Model of Postinfarction Mitral Regurgitation and Techniques to Accommodate Its Effects during Surgical Repair.

Author information

1
Structural Heart Disease Research and Innovation Laboratory, Division of Cardiothoracic Surgery, Carlyle Fraser Heart Center, Emory University, Atlanta, Georgia, USA.
2
Cardiac Perfusion Services, Emory Healthcare, Atlanta, Georgia, USA.
3
Structural Heart Disease Research and Innovation Laboratory, Division of Cardiothoracic Surgery, Carlyle Fraser Heart Center, Emory University, Atlanta, Georgia, USA. spadala@emory.edu.

Abstract

Mitral regurgitation (MR) is a common heart-valve lesion after myocardial infarction in humans. Because it is considered a risk factor for accelerated heart failure and death, various surgical approaches and catheter-based devices to correct it are in development. Lack of a reproducible animal model of MR after myocardial infarction and reliable techniques to perform open-heart surgery in these diseased models led to the use of healthy animals to test new devices. Thus, most devices that are deemed safe in healthy animals have shown poor results in human efficacy studies, hampering progress in this area of research. Here we report our experience with a swine model of postinfarction MR, describe techniques to induce regurgitation and perform open-heart surgery in these diseased animals, and discuss our outcomes, complications, and solutions.

PMID:
27538860
PMCID:
PMC4983171
[Indexed for MEDLINE]
View Full Article
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons